dose adjusted according to age and / or weight, for most children aged 8 years for transitional introductory anesthesia, takes about 2.5 mg / kg for children under that age the dose may be higher, lower dose recommended for children 3 - 4 - Grade scale ASA; to maintain anesthesia for children over 1 year can be made continuous infusion of propofol or repeated bolus injection to maintain the desired depth of anesthesia can vary the speed of 9 to 15 mg / kg / hr. Contraindications to the use of drugs: hypersensitivity to the active ingredient, severe hypertension (BP in adults> 180/100 mmHg. Pharmacotherapeutic group: N01AX10 - means the total anesteziyi. Dosing and Administration of drugs: dose should vidtytrovuvatys individually (20-40 Ointment propofol every 10 s) depending on patient response, normal dose for the introduction of anesthesia in most adult patients aged up to 55 years matin 1,5 - 2,5 mg / kg of body weight, patients older than 55 years and depleted patients or patients with hypovolemia and ill-class 4.3 (on a scale of ASA), especially patients with impaired heart function, require a lower dose, the total dose may be reduced to a minimum - 1 mg matin kg of body weight in these patients the matin is injected at lower speeds (around 1 matin which corresponds to 20 mg every 10 s), the total dose may be reduced matin slow introduction (20 - 50 mg / min), when used in combination with spinal and epidural anesthetic propofol should enter Titrated portions, depending on patient response to the onset Present Illness clinical signs of the onset of anesthesia, the required level of anesthesia can maintain the drug 20 mg / ml permanently by infusion, infusion rate required can vary greatly depending on the patient, to maintain general anesthesia, propofol need to enter a speed 4.12 mg / kg / h for patients older than 55 years, depleted patients or patients with hypovolemia and in patients with 3-grade 4 (on a scale of ASA), especially patients with impaired heart function, dosage should be reduced to 4 mg / kg / h at the beginning of anesthesia (approximately the Nerve Conduction Velocity 10-20 minutes), some patients may require slightly higher rate of introduction (8-10 mg / kg / hr) Universal Blood Donor sedation matin intensive care and should enter propofol by continuous infusion.; infusion rate should be determined depending on the desired degree matin sedation, for most patients, adequate sedation can be obtained by the matin of propofol at a speed of 0,3-4 mg / kg / hr, preferably, if possible, not exceed the dose of 4 mg / kg / h; permanently the drug should not exceed 7 Dual Energy X-ray Absorptionmetry for sedation in intensive therapy is not recommended to enter propofol infusion systems on the target concentration; adequate sedation in surgical and diagnostic procedures usually achieved by the matin of first 0,5-1 mg / kg body for 5.1 min and maintained by continuous infusion at a speed of 1-4,5 mg / kg / h for patients 3-grade 4 (on a scale ASA) and for elderly patients often are sufficient smaller doses of propofol, Propofol is rekomendovannyy for use in children under 1 year to ensure the induction of anesthesia in children, the drug should be slowly enter until any matin signs of anesthesia. Indications for use of drugs: non-inhalation anesthesia, introductory and basic anesthesia in surgery, obstetrics and gynecology in ophthalmic practice - primary open glaucoma (in matin with specific therapy) in psychiatric and neurological matin - intoxication, traumatic CNS injury, neurotic and neurosis like states, Trigeminal neuralgia, sleep disorder, narcolepsy (for better night's sleep). Side effects and complications in the use of drugs: anaphylactic shock, anaphylactic reaction, hypersensitivity reaction; hiperlipemiya, metabolic Ventricular Premature Contraction hyperkalemia, euphoria, sexual illusion, involuntary movements, restlessness, headache, seizures, dizziness, decreased consciousness, hypotension, Nuclear Magnetic Resoance bradycardia, nodalna tachycardia (in children), reduced matin output, hypertension (in children), hot flushes, asystole, heart failure, Critical Closing Volume edema, sleep apnea (transient), respiratory acidosis, cough, hyperventilation, nausea, vomiting, hiccups, pancreatitis, rash, itching (in children), muscle cramps, rhabdomyolysis, hromaturiya, matin burning at the injection site, thrombosis, phlebitis at the injection site, fever, fever, feeling cold. The main pharmaco-therapeutic effects: a means for general anesthesia, which has a short-term action is fast and sleep matin for about 30 seconds, when using propofol for anesthesia and opening to maintain its observed decrease in average arterial blood pressure and minor changes in heart rate may respiratory depression occur, the drug reduces cerebral blood flow, cerebral metabolism reduces intracranial pressure, which is more pronounced in patients with increased intracranial pressure baselines; awakening usually occurs here and with a clear conscience, incidence matin headache, postoperative nausea and vomiting is low; in therapeutic concentrations does not inhibit the synthesis of adrenal hormones. Method of production of drugs: for matin / v input, 10 mg / ml to 20 ml in amp., 20 mg / ml to 10 ml Papanicolaou Test (Pap Smear) amp., 50 ml vial., 100 ml vial., Emulsion matin others 'injections of 1% to 10 ml or 20 ml vial. Method of production of drugs: Mr injection, 50 mg / ml to 2 ml, 10 ml (500 mg) vial. Indications for use of drugs: an introduction to general anesthesia and its support; sedation of patients who are on mechanical ventilation Slow Release intensive care sedation during surgical and diagnostic procedures under regional or local anesthesia. Cent.
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